HPV DNA Genotyping Test
- Cervical cancer is caused by human papillomavirus (HPV) infection.
- The HPV test captures the known cancer causing viruses.
- Human papillomavirus (HPV) is the most commonly transmitted sexual infection, and most sexually active people—men and women—will get it.
- Although the virus is spread sexually, its presence doesn't mean that you've been promiscuous or unfaithful. Nor does its presence mean you will get cancer. In fact, most women have no symptoms, and the virus goes away on its own.
- In some women, the virus persists for years after the initial infection, and it is at risk of eventually developing cell changes that could lead to cancer.
- HPV testing is more sensitive than the cytology test for detecting precancer.
- Our HPV DNA Genotyping test is specific detect of 21 HPV subtypes:
- 15 High Risk subtype (oncogenic): HPV 16, 18, 31, 33, 35, 39, 45, 51,52, 53, 56, 58, 59, 66, 68.
- 6 Low Risk subtype : HPV 6, 11, 42, 43, 44, 81.
- Persistent infection with HPV is the principal cause of cervical cancer and its precursor cervical intraepithelial neoplasia (CIN).
- Knowing the genotypes of HPV is important and beneficial:
- Beware of persistent infections
More than 90% HPV infections go away on their own within 6 to 24 months. Persistent HPV infection is critical risk factor of cervical carcinogenesis (National Cancer Institute). Persistency can only be recognized by genotyping when someone having been infected with identical HPV subtypes in 2 consecutive years. This is the advantage of HPV genotyping test over non-genotyping one. - Different HPV subtypes leading to a different management.
Positive HPV subtypes 16 and 18 test result is mandatory to colposcopy regardless of cytology results. Non HPV 16 and 18 subtypes may be observed for next 12 months.
- The laboratory uses the HPV XpressMatrix™ Kit in its testing which is a local production kit and has registered from the Ministry of Health of Indonesia and passed the proficiency test.
